Ishwarlal Jialal Selected Research

Simvastatin (Zocor)

6/2008	Simvastatin reduces circulating plasminogen activator inhibitor 1 activity in volunteers with the metabolic syndrome.
11/2007	Simvastatin (40 mg/day), adiponectin levels, and insulin sensitivity in subjects with the metabolic syndrome.
8/2007	Concomitant reduction of low-density lipoprotein-cholesterol and biomarkers of inflammation with low-dose simvastatin therapy in patients with type 1 diabetes.
11/2006	Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome.
2/2002	Effects of simvastatin (40 and 80 mg) on highly sensitive C-reactive protein in patients with combined hyperlipidemia.

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Ishwarlal Jialal Research Topics

Disease

71	Inflammation (Inflammations) 01/2023 - 09/2002
53	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2023 - 01/2003
33	Cardiovascular Diseases (Cardiovascular Disease) 06/2023 - 01/2002
30	Insulin Resistance 01/2023 - 03/2003
30	Atherosclerosis 01/2016 - 01/2002
12	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2022 - 03/2006
11	Thrombosis (Thrombus) 12/2011 - 03/2002
10	Type 2 Diabetes Mellitus (MODY) 01/2022 - 03/2002
8	Obesity 09/2023 - 07/2008
8	Hyperglycemia 05/2016 - 01/2005
7	Hypertriglyceridemia 01/2023 - 03/2002
7	Body Weight (Weight, Body) 01/2022 - 01/2005
7	Dyslipidemias (Dyslipidemia) 01/2021 - 03/2002
4	Hypercholesterolemia 01/2023 - 09/2006
4	Hypertension (High Blood Pressure) 01/2019 - 02/2011
4	Weight Loss (Weight Reduction) 11/2014 - 01/2005
3	Hypoglycemia (Reactive Hypoglycemia) 01/2022 - 11/2014
3	Fibrosis (Cirrhosis) 01/2021 - 11/2014
3	Neoplasms (Cancer) 12/2018 - 10/2011
3	Diabetic Angiopathies (Diabetic Angiopathy) 01/2016 - 07/2015
3	Hyperlipidemias (Hyperlipidemia) 02/2014 - 02/2002
3	Atherosclerotic Plaque (Atheroma) 02/2009 - 03/2004
2	Autoimmune Diseases (Autoimmune Disease) 03/2022 - 01/2022
2	Insulinoma 01/2022 - 11/2014
2	Pancreatitis 05/2019 - 08/2010
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2017 - 03/2002
2	Chronic Renal Insufficiency 01/2017 - 03/2012
2	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2016 - 01/2014
2	Wounds and Injuries (Trauma) 09/2013 - 11/2010
2	Acute Coronary Syndrome 06/2013 - 02/2009
2	Hemolysis 03/2012 - 03/2002

Drug/Important Bio-Agent (IBA)

53	C-Reactive ProteinIBA 01/2023 - 02/2002
48	Biomarkers (Surrogate Marker)IBA 10/2023 - 12/2002
19	Toll-Like Receptors (Toll-Like Receptor)IBA 05/2016 - 02/2008
14	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 09/2023 - 03/2002
13	oxidized low density lipoproteinIBA 05/2023 - 03/2002
13	Proteins (Proteins, Gene)FDA Link 09/2022 - 01/2005
13	CytokinesIBA 09/2019 - 12/2002
11	Insulin (Novolin)FDA Link 01/2023 - 03/2003
11	AdipokinesIBA 01/2023 - 01/2013
10	LDL CholesterolIBA 05/2023 - 01/2007
10	Triglycerides (Triacylglycerol)IBA 01/2023 - 03/2002
10	HDL CholesterolIBA 01/2022 - 03/2002
10	AdiponectinIBA 11/2021 - 11/2007
10	Interleukin-6 (Interleukin 6)IBA 01/2019 - 12/2002
9	alpha-Tocopherol FDA Link 03/2008 - 01/2002
9	AntioxidantsIBA 05/2006 - 01/2002
8	LipidsIBA 06/2023 - 02/2004
8	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 03/2003
7	LeptinIBA 11/2021 - 11/2011
7	LDL Lipoproteins (beta Lipoproteins)IBA 05/2019 - 03/2002
6	InterleukinsIBA 01/2019 - 01/2005
6	Superoxides (Superoxide)IBA 10/2012 - 03/2006
6	Plasminogen Activators (Plasminogen Activator)IBA 10/2005 - 03/2002
5	Messenger RNA (mRNA)IBA 03/2019 - 01/2005
5	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2017 - 08/2006
5	Pattern Recognition ReceptorsIBA 11/2014 - 02/2011
5	Human Serum Albumin FDA LinkGeneric 11/2013 - 03/2009
5	Simvastatin (Zocor)FDA LinkGeneric 06/2008 - 02/2002
4	Nonesterified Fatty Acids (NEFA)IBA 01/2023 - 04/2010
4	NF-kappa B (NF-kB)IBA 01/2010 - 01/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2010 - 12/2002
3	AutoantibodiesIBA 03/2022 - 03/2002
3	Hydrocortisone (Cortisol)FDA LinkGeneric 08/2021 - 11/2017
3	HDL LipoproteinsIBA 01/2021 - 08/2010
3	InflammasomesIBA 01/2021 - 01/2017
3	p38 Mitogen-Activated Protein KinasesIBA 01/2019 - 01/2016
3	Streptozocin (Streptozotocin)FDA Link 01/2017 - 09/2011
3	Cell Adhesion MoleculesIBA 04/2016 - 12/2004
3	Vitamin A (Retinol)FDA LinkGeneric 12/2014 - 11/2011
3	Toll-Like Receptor 4IBA 11/2014 - 02/2011
3	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2014 - 03/2006
3	3-nitrotyrosineIBA 10/2012 - 03/2006
3	Plasminogen Activator Inhibitor 1IBA 10/2011 - 01/2003
3	P-SelectinIBA 06/2008 - 03/2002
2	Insulin ReceptorIBA 03/2022 - 01/2022
2	Lipoprotein(a)IBA 01/2022 - 03/2002
2	CreatinineIBA 01/2022 - 05/2007
2	Interleukin-18 (Interleukin 18)IBA 01/2021 - 01/2017
2	Apolipoproteins B (ApoB)IBA 01/2021 - 12/2016
2	EndotoxinsIBA 07/2020 - 11/2014
2	alpha-2-HS-GlycoproteinIBA 07/2020 - 07/2015
2	Atorvastatin (Lipitor)FDA Link 01/2020 - 08/2008
2	ChemokinesIBA 09/2019 - 12/2004
2	Lipoproteins (Lipoprotein)IBA 05/2019 - 03/2002
2	Blood Glucose (Blood Sugar)IBA 01/2019 - 02/2013
2	CollagenIBA 01/2019 - 11/2014
2	Serum Amyloid A Protein (Serum Amyloid A)IBA 01/2017 - 11/2011
2	ResistinIBA 11/2016 - 03/2013
2	Folic Acid (Vitamin M)FDA LinkGeneric 08/2016 - 03/2003
2	Small Interfering RNA (siRNA)IBA 05/2016 - 01/2014
2	Peptides (Polypeptides)IBA 05/2016 - 01/2014
2	Interleukin-8 (Interleukin 8)IBA 04/2016 - 03/2004
2	Retinaldehyde (Retinal)IBA 01/2016 - 01/2014
2	lipopolysaccharide-binding proteinIBA 07/2015 - 11/2014
2	NPHS2 proteinIBA 11/2014 - 08/2011
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2014 - 11/2006
2	BilirubinIBA 03/2012 - 03/2002

Therapy/Procedure

25	Therapeutics 09/2023 - 03/2002
4	Drug Therapy (Chemotherapy) 01/2019 - 11/2007